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In recent times, supplemental considerations are raised concerning the basic safety of diphenhydramine. In 2019, the Canadian Culture of Allergy and Scientific Immunology published a situation statement, recommending the usage of newer-generation about to start with-technology antihistamines for that remedy of allergic rhinitis and urticaria because of the unfavourable risk-advantage profile of initial-generation antihistamines.Footnote 3

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